反应详情

An aqueous sodium hydroxide (19.2 g, 480 mmol) solution was added to a methanol (250 mL) solution of the compound obtained in Example 19 (35.1 g, 96 mmol), and the mixture was refluxed while heating for 2 hours. After allowing the mixture to cool in the air, the solvents were distilled off under a reduced pressure, and water was added to the residue. The solution was neutralized with hydrochloric acid, and the precipitated crystals were separated by filtration and dried, to give 30.0 g (97%) of the captioned compound.

1. temperaturethe mixture was refluxed
2. temperaturewhile heating for 2 hours
3. temperatureto cool in the air
4. distillationthe solvents were distilled off under a reduced pressure, and water
5. additionwas added to the residue
6. customthe precipitated crystals were separated by filtration
7. customdried