反应详情

An aqueous sodium hydroxide (1.4 g, 680 mmol) solution was added to an ethanol (40 mL) solution of the compound obtained in Example 24 (2.9 g, 6.7 mmol), and the mixture was refluxed while heating for 2 hours. After allowing the mixture to cool in the air, the solvents were distilled off under a reduced pressure, water was added to the residue, and the mixture was neutralized with hydrochloric acid. The precipitated crystals were separated by filtration and dried, to give 1.3 g (50%) of the captioned compound.

1. temperaturethe mixture was refluxed
2. temperaturewhile heating for 2 hours
3. temperatureto cool in the air
4. distillationthe solvents were distilled off under a reduced pressure, water
5. additionwas added to the residue
6. customThe precipitated crystals were separated by filtration
7. customdried