Sodium Hydroxide → HCID 44195252, compound

HRID 389037Notes

Reaction equation

HRID 389037 reaction equation
[OH-].[Na+].[O:3]=[C:4]([CH3:33])[CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][C:11](=[C:14]2[C:23]3[CH:24]=[C:25]([CH2:28][C:29]([O:31]C)=[O:30])[CH:26]=[CH:27][C:22]=3[O:21][CH2:20][C:19]3[CH:18]=[CH:17][S:16][C:15]2=3)[CH2:10][CH2:9]1>C(O)C>[O:3]=[C:4]([CH3:33])[CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][C:11](=[C:14]2[C:23]3[CH:24]=[C:25]([CH2:28][C:29]([OH:31])=[O:30])[CH:26]=[CH:27][C:22]=3[O:21][CH2:20][C:19]3[CH:18]=[CH:17][S:16][C:15]2=3)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86649446HCID 86649446, compound

Product 1

HCID 44195252HCID 44195252, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 2 mol/L aqueous sodium hydroxide solution (5 mL, equivalent to 10 mmol sodium hydroxide) was added to an ethanol (20 mL) solution of the compound obtained in Example 30 (2.40 g, 5.5 mmol), and the mixture was stirred at room temperature for 2 hours. The solvents were distilled off, water was then added to the residue, and the aqueous solution was adjusted to a pH of 7 with a diluted hydrochloric acid. The precipitated crystals were separated by filtration and dried, to give 1.30 g (56%) of the captioned compound.

Workup

  1. distillationThe solvents were distilled off
  2. additionwater was then added to the residue
  3. customThe precipitated crystals were separated by filtration
  4. customdried

Sources & evidence

ORD record
ord-f94b062c06f0439b8b3248b3da5ac42b
Source dataset
uspto-grants-2013_02
Patent number
US08377967B2

Reaction notes

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