Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 38904생성일: 2026년 10월 26일
3-Methylpiperidine → 3-Methyl-1-{[(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}piperidine
https://huagongshe.com/reaction/38904
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Methylpiperidine | HCID 79081 | — |
| 반응물 | [(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate | HCID 86652934 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-Methyl-1-{[(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}piperidine | HCID 44469458 | — |
반응 단계
A mixture of [(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.20 g, 0.5 mmol), 3-methylpiperidine (0.35 ml, 3 mmol) and ACN (2 ml) was heated under microwave radiation at 120° C. for 30 min. Purification on flash column chromatography (Isooctane/EtOAc/MeOH). Yield: 0.097 g, 85%. The amine was converted to the fumaric acid salt and crystallized from MeOH/(i-Pr)2O. M.p. 159° C. MS m/z (rel. intensity, 70 eV) 325 (M+, 1), 113 (83), 112 (bp), 69 (43), 55 (46). [α]=+50° (MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524766B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-b456ce4360a84ba2ac3b3cb60427655f |
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| 출처 메모 | uspto-grants-2013_09 |
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