Sodium Hydroxide → HCID 44181045, compound

HRID 389041Notes

Reaction equation

HRID 389041 reaction equation
[OH-].[Na+].[NH:3]1[CH2:8][CH2:7][C:6](=[C:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH:16]=[CH:15][C:14]3[S:13][C:12]([CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])=[CH:11][C:10]2=3)[CH2:5][CH2:4]1>C(O)C>[NH:3]1[CH2:4][CH2:5][C:6](=[C:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH:16]=[CH:15][C:14]3[S:13][C:12]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:11][C:10]2=3)[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68489011HCID 68489011, compound

Product 1

HCID 44181045HCID 44181045, compoundYield 59.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 2 mol/L aqueous sodium hydroxide solution (10 mL, equivalent to 20 mmol of sodium hydroxide) was added to an ethanol (30 mL) solution of the compound obtained in Example 36 (2.0 g, 5.3 mmol), and the mixture was stirred at room temperature for 2 hours. The solvents were distilled off, water was then added to the residue, and the mixture was adjusted to a pH of 7 with a diluted hydrochloric acid. The precipitated crystals were separated by filtration and dried, to give 1.1 g (59%) of the captioned compound.

Workup

  1. distillationThe solvents were distilled off
  2. additionwater was then added to the residue
  3. customThe precipitated crystals were separated by filtration
  4. customdried

Sources & evidence

ORD record
ord-376fa98d048a459cb34cd5ef56da5348
Source dataset
uspto-grants-2013_02
Patent number
US08377967B2

Reaction notes

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