1-Aminopiperidine → HCID 21328006, compound

HRID 389046Notes

Reaction equation

HRID 389046 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[N:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([NH:12][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 31297Methanesulfonyl chloride

Product 1

HCID 21328006HCID 21328006, compound

Procedure

TEA (2.43 mL, 17.46 mmol) and methanesulfonylchloride (2.0 g, 17.46 mmol). were added to a solution of piperidin-1-ylamine Compound 1i1 (1.75 g, 17.46 mmol) at 0° C., under a N2 atmosphere. The mixture was stirred for 3 hrs, while warming to r.t. The reaction was quenched with water (20 mL) and the organic layer was diluted with CH2Cl2 (100 mL), washed with water and brine, separated and dried with anhydrous sodium sulfate, then filtered and concentrated in vacuo to yield N-piperidin-1-yl-methanesulfonamide Compound 1i2 as an oil.

Workup

  1. customThe reaction was quenched with water (20 mL)
  2. additionthe organic layer was diluted with CH2Cl2 (100 mL)
  3. washwashed with water and brine
  4. customseparated
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-45e36a41efc949fc94c1a987fb7d28fb
Source dataset
uspto-grants-2013_02
Patent number
US08378096B2

Reaction notes

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