HCID 178526874, compound → HCID 178508078, compound

Participants

Reaction Steps

In step (4) of Reaction Scheme V, a benzyloxy-3-nitroquinolin-4-ol or benzyloxy-3-nitro[1,5]naphthyridin-4-ol of Formula XLVI is reduced to provide a 3-amino-benzyloxyquinolin-4-ol or 3-aminobenzyloxy[1,5]naphthyridin-4-ol of Formula XLVII. The reaction can be carried out by hydrogenation using a heterogeneous hydrogenation catalyst such as platinum on carbon. The hydrogenation is conveniently carried out in a Parr apparatus in a suitable solvent such as dimethylformamide (DMF). The reaction can be carried out at ambient temperature, and the product or the hydrochloride salt thereof can be isolated using conventional methods.

Provenance & Evidence