m-Chloroperbenzoic acid → HCID 67545303, compound

Participants

Reaction Steps

3-Chloroperoxybenzoic acid (mCPBA) (34.7 grams (g) of 77% purity, 155 millimoles (mmol)) was added over a period of 15 minutes to a solution of [1,3]thiazolo[4,5-c]quinolin-2-ylmethyl acetate (U.S. Pat. No. 6,110,929, Example 37 Parts A and B, 20.0 g, 77.4 mmol) in chloroform (500 milliliters (mL)), and the reaction was stirred for two hours at room temperature and subsequently washed with aqueous sodium carbonate (500 mL of 10% weight/weight (w/w)). The organic layer was dried over magnesium sulfate and filtered to provide a solution of (5-oxido[1,3]thiazolo[4,5-c]quinolin-2-yl)methyl acetate in chloroform.

Provenance & Evidence