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HRID 38906作成日：2026年10月25日
Isobutylamine → 2-Methyl-N-{[(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}propan-1-amine
https://huagongshe.com/reaction/38906
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isobutylamine | HCID 6558 | — |
| 反応物 | [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate | HCID 86652935 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Methyl-N-{[(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}propan-1-amine | HCID 44469596 | — |
反応手順
A mixture of [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.19 g, 0.48 mmol), 2-methylpropane-1-amine (0.9 ml) and ACN (3 ml) was heated under microwave radiation at 120° C. for 20 min. Purification on SCX-3 column (TEA/MeOH) and flash column chromatography (DCM/MeOH). Yield: 0.11 g, 74%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 214° C. MS m/z (rel. intensity, 70 eV) 299 (M+, 6), 86 (100), 256 (21), 57 (8), 70 (6). [α]=−58° (MeOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08524766B2 |
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| 出典データセット | uspto-grants-2013_09 |
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| ORD ID | ord-cfbb3531158c48fc852fede59e0efdef |
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| 出典メモ | uspto-grants-2013_09 |
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