Thionyl Chloride → HCID 67542708, compound

Participants

Reaction Steps

Thionyl chloride (4.92 mL, 67.6 mmol) was added to a suspension of (4-amino[1,3]thiazolo[4,5-c]quinolin-2-yl)methanol (13 g, 56 mmol) in 1,2-dichloroethane (300 mL), and the reaction was heated at reflux for two hours and then concentrated under reduced pressure to provide 16 g of 2-(chloromethyl)[1,3]thiazolo[4,5-c]quinolin-4-amine hydrochloride as a yellow solid.

Provenance & Evidence