反应详情

温度

60 °C

A solution of 7-bromoquinolin-4-ol (594 g, 2.65 mol) in propionic acid (5 L) was heated to 120° C., and nitric acid (215 mL of 16 molar (M)) was added dropwise over a period of 2.5 hours while maintaining the temperature in the range of 119° C. to 130° C. The reaction was then cooled to 60° C. and filtered to collect a solid, which was washed sequentially with water (3×500 mL), 2-propanol (500 mL), and diethyl ether (300 mL), and pulled dry with vacuum filtration to provide 447 g of 7-bromo-3-nitroquinolin-4-ol as a tan powder.

1. temperaturewhile maintaining the temperature in the range of 119° C. to 130° C
2. filtrationfiltered
3. customto collect a solid, which
4. washwas washed sequentially with water (3×500 mL), 2-propanol (500 mL), and diethyl ether (300 mL)
5. custompulled dry with vacuum filtration