N-Hydroxyphthalimide → HCID 67542029, compound

Participants

Reaction Steps

N-Hydroxyphthalimide (4.15 g, 25.4 mmol) and triphenylphosphine (6.66 g, 25.4 mmol) were added to a suspension of (7-bromo[1,3]thiazolo[4,5-c]quinolin-2-yl)methanol (5.00 g, 16.9 mmol) in THF (170 mL). Diethyl azodicarboxylate (4.43 g, 25.4 mmol) was added dropwise, and the resulting solution was stirred at room temperature for 1.5 hours. A precipitate formed and was isolated by filtration, washed with THF, and dried in a vacuum oven to provide 5.59 g of 2-[(7-bromo[1,3]thiazolo[4,5-c]quinolin-2-yl)methoxy]-1H-isoindole-1,3(2H)-dione.

Provenance & Evidence