Triacetoxyperiodinane → 7-Bromo[1,3]thiazolo[4,5-c]quinoline-2-carbaldehyde

Participants

Reaction Steps

Dess-Martin periodinane (2.16 g, 5.08 mol, [1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one]) was added to a suspension of (7-bromo[1,3]thiazolo[4,5-c]quinolin-2-yl)methanol (prepared in Part F of Example 2, 1.0 g, 3.4 mmol) in dichloromethane (30 mL), and the resulting suspension was stirred at room temperature for 1.5 hours. The reaction mixture was filtered to isolate solid, which was washed with dichloromethane and diethyl ether to provide 877 mg of 7-bromo[1,3]thiazolo[4,5-c]quinoline-2-carbaldehyde as a brown solid.

Provenance & Evidence