反应详情

3b is prepared from 2b according to the protocol described for 3a; 2b (4.7 g, 14.4 mmol), 14.4 ml DMSO, 14.4 ml Et3N, and Me3N.SO3 (4 g, 28.8 mmol). The product is purified by chromatography on a silica column, eluent: C6H12/Et2O (80:20) to give a yellow solid (4.51 g, 96%); 1H NMR (100 MHz, CDCl3) δ: 2.82-3.01 (m, 4H), 4.38 (d, J=5 Hz, 2H), 6.4 (m, 1H), 7.23-7.84 (m, 9H). Analysis calculated for C18H16N3OCl: C, 66.36; H, 4.95; N, 12.90. Experimental: C, 66.53; H, 5.23; N, 12.78.

1. customThe product is purified by chromatography on a silica column, eluent