tert-Butyl carbazate → HCID 67024448, compound

Participants

Reaction Steps

2-[(4-chloro-1-naphthyl)oxy]-2-methylpropanoic acid (6.66 g), WSC•monohydrochloride (6.0 g) and N,N-dimethylaminopyridine (200 mg) were dissolved in acetonitrile (70 ml), tert-butyl carbazate (4.0 g) was added thereto, followed by stirring at room temperature overnight. The solvent was concentrated under reduced pressure, water was added thereto, followed by extraction portionwise with chloroform, and the organic layer was washed with saturated brine. After drying over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform:methanol) to obtain tert-butyl 2-{2-[(4-chloro-1-naphthyl)oxy]-2-methylpropanoyl}hydrazinecarboxylate (6.10 g).

Provenance & Evidence