Thiourea → Methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate hydrobromide

Participants

Reaction Conditions

Reaction Steps

Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.3 g) and thiourea (900 mg) were dissolved in ethanol (20 ml) followed by stirring at 80° C. overnight. After cooling to room temperature, the solvent was evaporated under reduced pressure, and the residue was washed with isopropanol to obtain, as a grayish white solid, methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate monohydrobromide (2.82 g).

Provenance & Evidence