Tetrahydrofuran → HCID 58243583, compound

Participants

Reaction Steps

Ethyl isothiocyanate (0.60 ml) was added to a solution of ethyl piperidine-4-carboxylate (1.02 g) in THF (20 ml), followed by stirring at room temperature for one hour. The reaction solution was concentrated and the resulting colorless oily product was made into an ethanol solution (20 ml), iodomethane (2.0 ml) was added thereto, followed by stirring at 60° C. for 3 hours. The reaction solution was concentrated, an aqueous saturated sodium hydrogen carbonate solution was added thereto, followed by extraction with chloroform, the organic layer was washed with saturated brine and was dried over anhydrous magnesium sulfate, and the solvent was evaporated to obtain ethyl 1-[(ethylimino)(methylsulfanyl)methyl]piperidine-4-carboxylate (1.84 g) as a light yellow oily product.

Provenance & Evidence