Dimethylformamide → HCID 58243511, compound

Participants

Reaction Steps

Sodium hydride (53 mg) was added to a mixture of 1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethanol (300 mg) and DMF (10 ml) at room temperature, followed by stirring for 10 minutes, and 2-chloro-3-cyanopyridine (153 mg) was added thereto, followed by stirring at room temperature for 13 hours. Water and chloroform were added to the reaction solution, followed by separation operation, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=100:1) to obtain, as a light yellow amorphous product, 2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinonitrile (306 mg).

Provenance & Evidence