Water → HCID 86653018, compound

Participants

Reaction Conditions

Reaction Steps

4-{4-methyl-5-[1-methyl-1-(2,4,6-trifluorophenoxy)ethyl]-4H-1,2,4-triazol-3-yl}-3-(trifluoromethyl)phenol monohydrochloride (123 mg) was suspended in DMF (3 ml), and potassium carbonate (182 mg) and ethyl bromoacetate (0.060 ml) were added thereto, followed by stirring at 60° C. for one hour. The reaction solution was cooled to room temperature and water was added thereto followed by extraction with ethyl acetate. The organic layer was sequentially washed with water and saturated brine in this order and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting residue was dissolved in ethyl acetate, 4M hydrogen chloride-ethyl acetate (1 ml) was added thereto and the solvent was evaporated under reduced pressure. The residue was washed with diisopropylether to obtain, as a white solid, ethyl [4-{4-methyl-5-[1-methyl-1-(2,4,6-trifluorophenoxy)ethyl]-4H-1,2,4-triazol-3-yl}-3-(trifluoromethyl)phenoxy}acetate monohydrochloride (68 mg).

Provenance & Evidence