Methylamine → HCID 58243770, compound

Participants

Reaction Steps

Ethyl N-[5-chloro-2-(1-methyl-1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)benzoyl]glycinate (300 mg) was dissolved in ethanol (6 ml), and methylamine (2.86 ml) was added thereto, followed by stirring at room temperature for one hour. Potassium carbonate (240 mg) was added thereto, followed by stirring at 60° C. for one hour. Methylamine (2.86 ml) was added thereto, followed by stirring at 60° C. for 2 hours. The reaction solution was cooled to room temperature and water and a 1M aqueous sodium hydroxide solution were added thereto, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting solid was washed with diisopropylether to obtain, as a white solid, 5-chloro-N-[2-(methylamino)-2-oxoethyl]-2-(1-methyl-1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)benzamide (131 mg).

Provenance & Evidence