Triphosgene → HCID 59571236, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (2S)-1-ethoxy-1-oxononan-2-aminium chloride (4.00 g, 16.97 mmol) and DCM (80 ml) was cooled to 0° C. A solution of saturated NaHCO3 (80.0 ml, 84 mmol) was added, and then triphosgene (1.662 g, 5.60 mmol) was added. The reaction mixture was stirred at 0° C. for 1 hour, and then the layers were separated. The aqueous layer was extracted with DCM (3×). The combined organic portions were washed with brine, dried with MgSO4 and filtered and concentrated. The crude product was subjected to silica gel chromatography (80:20 hexane/EtOAc) to give the title compound.

Provenance & Evidence