Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl 3-[(4-bromo-3-methoxyphenyl)amino]-3-phenylacrylate | HCID 58005168 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | HCID 57617105 | HCID 57617105 | 88.5% |
Reaction Steps
DOWTHERM A (450 mL) was heated to reflux (˜300° C.). A mixture of the product from Step 2 (49 g, 130 mmol) in DOWTHERM A (50 mL) was added to the heated Dowtherm A portionwise, and the mixture stirred at reflux for 30 minutes after addition was complete. The mixture was cooled to RT; hexane (400 mL) was added; and the mixture was stirred for 30 minutes, filtered, and the solids washed with hexane to give the title compound (38 g). LRMS (M+H)+ Calcd.: 330.0; found 330.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08377874B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-2b3a735fff97402f98584df7c705a2c4 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
