Hydrochloric Acid → HCID 59571129, compound

Participants

Reaction Steps

A mixture of the product from Step 1 (0.68 g, 1.02 mmol) in THF (7 mL), MeOH (1 mL) and 1 M aqueous LiOH (7.15 mL, 7.15 mmol) was stirred at RT for 2 hours. The reaction mixture was acidified to pH 5 with 1 M aqueous HCl and extracted with EtOAc (3×70 mL). The combined organic phases were washed with water (50 mL), brine (30 mL), dried over Na2SO4, filtered and concentrated to give the title compound (0.56 g). LRMS (ESI) m/z 656.5 [(M+H)+; calcd for C38H46N3O7: 656.3].

Provenance & Evidence