Hydrochloric Acid → HCID 59571253, compound

Participants

Reaction Steps

A solution of the product from Step 1 (962 mg, 1.38 mmol) in THF (10 mL), MeOH (1 mL) and 1 M aqueous LiOH (9.65 mL) was stirred at RT for 2 hours. The reaction solution was acidified to pH 5 with 1 M aqueous HCl and extracted with EtOAc (3×100 mL). The combined EtOAc layers were washed with water (50 mL), brine (30 mL), dried over Na2SO4, filtered and concentrated to give the title product (844 mg). LRMS (ESI) m/z 684.5 [(M+H)+; calcd for C40H50N3O7: 684.4].

Provenance & Evidence