HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 86647503, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59571194 | HCID 59571194 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86647503 | HCID 86647503 | — |
Reaction Steps
To a solution of the product from Step 2 (368 mg, 0.593 mmol), Intermediate A2 (136 mg, 0.712 mmol) and DIPEA (0.518 mL, 2.97 mmol) in DMF (10 mL) was added HATU (271 mg, 0.712 mmol). The solution was stirred at RT for 2 hours, diluted with EtOAc (150 mL), washed with water (3×50 mL), brine (50 mL), dried over Na2SO4, filtered and concentrated. The residue was chromatographed on silica gel, eluting with 5% to 75% EtOAc in hexane, to give the title product (411 mg). LRMS (ESI) m/z 757.4 [(M+H)+; calcd for C37H50BrN4O8: 757.3].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377874B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-a4c622686c5e453cb07f5bed6761c567 |
| Source note | uspto-grants-2013_02 |