HCID 86647503, compound → HCID 59571230, compound

Participants

Reaction Steps

A solution of the product from Step 3 (200 mg, 0.264 mmol) in dichloromethane (26 mL) was bubbled with nitrogen gas for 30 minutes. Zhan catalyst 1B (19.4 mg, 0.026 mmol) was added, and the reaction mixture was heated at reflux under nitrogen for 2 hours. The mixture was concentrated and chromatographed on silica gel 60, eluting with 5% to 75% EtOAc in hexane to give the title product (135 mg). LRMS (ESI) m/z 729.3 [(M+H)+; calcd for C35H46BrN4O8: 729.3].

Provenance & Evidence