Hydrochloric Acid → HCID 59571235, compound

Participants

Reaction Steps

To a solution of the compound from Step 1 (300 mg, 0.46 mmol) in MeCN (0.5 mL) was added Et3N (0.19 mL, 1.36 mmol). A solution of the compound from Step 2 (150 mg, 0.51 mmol) in MeCN (1.5 mL) was added, and the reaction mixture was stirred at RT for 1 hour. The reaction mixture was worked up with EtOAc and 1M HCl, and the organics were washed with brine, dried over Na2SO4, filtered and concentrated. The crude material was purified by silica gel chromatography (gradient elution 0 to 100% EtOAc in hexane). LCMS (M+H)+=792.0.

Provenance & Evidence