反应详情

53.3 g (0.334 mol) of bromine was added dropwise to a solution consisting of 61.1 g (0.332 mol) of 1-propionaphthone and 180 mL of ethanol at 50 to 55° C. After completion of addition, the ethanol was distilled off in vacuo, and the resulting concentrate was dissolved in 130 mL of toluene, washed with a mixed aqueous solution of sodium bicarbonate and sodium chloride (150 mL×two times), and then dried over sodium sulfate to obtain a toluene solution of 2-bromo-1′-propionaphthone.

1. additionAfter completion of addition
2. distillationthe ethanol was distilled off in vacuo
3. concentrationthe resulting concentrate
4. dissolutionwas dissolved in 130 mL of toluene
5. washwashed with a mixed aqueous solution of sodium bicarbonate and sodium chloride (150 mL×two times)
6. dry with materialdried over sodium sulfate