反应详情

2-Methyl-6-nitroquinoline (0.5 g, 2.66 mmol) and iodomethane (1 ml, 16 mmol) were heated together in acetonitrile (10 ml) at reflux for 48 hrs. The mixture was cooled to room temperature and a grey material crystallised out of solution and was filtered off. This was shown to be starting material. The filtrate was diluted with ethyl acetate (200 ml) to give a yellow/green precipitate. The product was filtered off, washed with ethyl acetate and then dried under vacuum. The product was obtained as a yellow/green solid (147 mg, 16.8%).

1. temperatureat reflux for 48 hrs
2. customa grey material crystallised out of solution
3. filtrationwas filtered off
4. additionThe filtrate was diluted with ethyl acetate (200 ml)
5. customto give a yellow/green precipitate
6. filtrationThe product was filtered off
7. washwashed with ethyl acetate
8. customdried under vacuum