Potassium Carbonate → HCID 58579970, compound

Participants

Reaction Conditions

Reaction Steps

[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester (0.672 g, 2.1 mmol), 2-chloro-3-pyridinecarbonitrile (0.274 g, 2.0 mmol), and potassium carbonate (0.966 g, 7.0 mmol) were combined in deoxygenated 2:1 DME:H2O (21 mL). Tetrakis(triphenylphosphine)palladium(0) (0.115, 0.1 mmol) was added, and the reaction was stirred at 70° C. for 1 hour. Once no starting material was seen by analytical LCMS and tlc, the mixture was worked-up and purified by silica gel chromatography to give the title compound.

Provenance & Evidence