Lithium Hydroxide → HCID 45255442, compound

Participants

Reaction Steps

(3-{3-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-quinolin-2-yl}-4-methoxy-phenyl)-acetic acid ethyl ester (0.272 g, 0.61 mmol) in THF (5 mL) and H2O (2 mL) was treated with lithium hydroxide (0.090 g, 2.1 mmol) and stirred at room temperature until no starting material was seen by analytical LCMS. The mixture was diluted with EtOAc and H2O, and citric acid was added to acidify the solution. The mixture was extracted with EtOAc, and the combined organic layers were washed with H2O, dried over MgSO4, filtered and concentrated to give the title compound.

Provenance & Evidence