[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester → HCID 58579980, compound

HRID 389287Notes

Reaction equation

HRID 389287 reaction equation
[C:1]([O:5][C:6](=[O:27])[N:7]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:8][C:9]1[C:18](Br)=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:28]([O:30][C:31](=[O:50])[CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[C:35](B2OC(C)(C)C(C)(C)O2)[CH:34]=1)[CH3:29]>>[CH2:28]([O:30][C:31](=[O:50])[CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[C:35]([C:18]2[C:9]([CH2:8][N:7]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:27])=[N:10][C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:34]=1)[CH3:29]

Participants

3

Reactant 2

HCID 58120060[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl esterHCID 58579967HCID 58579967, compound

Product 1

HCID 58579980HCID 58579980, compound

Procedure

Prepared according to the procedure described in Example 5, Step 3, using the following starting materials: benzyl-(3-bromo-quinolin-2-ylmethyl)-carbamic acid tert-butyl ester and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a8702b4a42f34f3a90477b1be7cb08aa
Source dataset
uspto-grants-2013_02
Patent number
US08378107B2

Reaction notes

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