Water → HCID 66812907, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 3-[4-(7-Methoxy-6-methyl-indan-4-ylmethyl)-3,5-dimethyl-pyrazol-1-yl]-propionic acid (1.0 gm, 0.00292 mole) in Tetrahydrofuran (20 ml), Carbonyl-diimidazole (0.62 gm, 0.0038 mole) was added at 20-30° C. The reaction mixture was heated and stirred for an hour at 70-75° C. A solution of Isopropyl amine (0.3 ml, 0.00367 mole) in Tetrahydrofuran (5 ml) was added at 20-30° C. The reaction mixture was further stirred at 70° C. for 4 hours. The reaction mixture was cooled and poured into water (50 ml) and extracted with Ethyl acetate (2×100 ml). The Ethyl acetate layer was dried over Sodium sulphate, distilled under vacuum to get a crude product which was stirred in Hexane (20 ml) and filtered to give 810 mg of desired product as a solid.

Provenance & Evidence