HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389312Generated: October 26, 2026
Water → 4-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one
https://huagongshe.com/reaction/389312
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 8-Methyl-3,4-dihydrocoumarin | HCID 23513095 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one | HCID 66812291 | 67.7% |
Reaction Steps
The mixture of 8-Methyl dihydrocoumarin (20 gm, 0.123 mole) and Aluminum trichloride (49.3 gm, 0.370 mole) was stirred for 2 hours at 175-180° C. To the reaction mixture, water (250 ml) was added slowly and stirred for an hour. Further it was filtered and obtained solid was stirred in Methanol (60 ml). Finally the suspension was filtered and obtained solid was dried under vacuum to give 13.5 gm of desired product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08378118B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-315445d0dd5c4e439bf36c7c5047aa8d |
|---|
| Source note | uspto-grants-2013_02 |
|---|
