HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389321Generated: October 29, 2026
Water → 4-Methoxy-5-methyl-2-(4-nitro-phenoxy)-indan-1-one
https://huagongshe.com/reaction/389321
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Bromo-4-methoxy-5-methyl-indan-1-one | HCID 66812711 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Methoxy-5-methyl-2-(4-nitro-phenoxy)-indan-1-one | HCID 66813095 | 73.7% |
Reaction Steps
To a stirred solution of 2-Bromo-4-methoxy-5-methyl-indan-1-one (2.0 gm, 0.0078 mole) in Dimethylformamide (15 ml), added Sodium salt of 4-Nitrophenol (1.27 gm, 0.0078 mole) at 10-15° C. After 2 hours stirring at 25-28° C., reaction mixture was poured into water (50 ml). The separated solid was filtered, washed with hexane and dried under vacuum to give 1.8 gm of desired product as a solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08378118B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-c8db2213d4254fee95be0bcfe6573f71 |
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| Source note | uspto-grants-2013_02 |
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