N-Methylpropylamine → HCID 44470157, compound

HRID 38933Notes

Reaction equation

HRID 38933 reaction equation
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12]OS(C3C=CC(C)=CC=3)(=O)=O)[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[CH3:28][NH:29][CH2:30][CH2:31][CH3:32]>C(#N)C>[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12][N:29]([CH3:28])[CH2:30][CH2:31][CH3:32])[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:25])=[O:26])[CH:3]=1

Participants

4

Reactant 2

HCID 12315N-MethylpropylamineHCID 86652936[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44470157HCID 44470157, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), N-methyl-propan-1-amine (0.5 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 317 (M+, 0.5), 288 (8), 86 (bp), 84 (6), 58 (8).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-aa3a650500094cd0bf048d08e19b7cee
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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