Azetidine → HCID 44470156, compound

HRID 38938Notes

Reaction equation

HRID 38938 reaction equation
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12]OS(C3C=CC(C)=CC=3)(=O)=O)[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[NH:28]1[CH2:31][CH2:30][CH2:29]1>C(#N)C>[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12][N:28]3[CH2:31][CH2:30][CH2:29]3)[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:25])=[O:26])[CH:3]=1

Participants

4

Reactant 2

HCID 10422AzetidineHCID 86652936[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44470156HCID 44470156, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), azetidine (0.1 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 301 (M+, 1), 244 (3), 71 (5), 70 (bp), 69 (4).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-c47250b0eae84e03bb90ec6265356e47
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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