反应详情

To a solution of Example 3 product (i.e., N-benzyl-O-methyl-N2-trityl-D-serinamide, 50 g) in absolute ethanol (100 ml), acetic acid (1.25 mole eq.) was added at room temperature. This solution was stirred for 30 minutes at room temperature and then the solvent was completely recovered under vacuum at 40° C. Water (250 ml) was added to it at room temperature and the aqueous layer was neutralized with aqueous ammonia (20 ml). The aqueous layer was extracted with toluene (2×200 ml). The toluene was then completely recovered under vacuum at 50° C. to 55° C. to get an oil. Yield=18 gm.

1. customthe solvent was completely recovered under vacuum at 40° C
2. additionWater (250 ml) was added to it at room temperature
3. extractionThe aqueous layer was extracted with toluene (2×200 ml)
4. customThe toluene was then completely recovered under vacuum at 50° C. to 55° C.
5. customto get an oil