4-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amine → 4-Iodo-2-phenylfuro[2,3-c]pyridin-7-amine

HRID 389434Notes

Reaction equation

HRID 389434 reaction equation
C1(C2OC3=C(N)N=CC=C3C=2)C=CC=CC=1.[I:17][C:18]1[CH:23]=[N:22][C:21]([NH2:24])=[C:20]2[O:25][C:26]([C:28]3[CH:37]=[CH:36][CH:35]=[C:34]4[C:29]=3C=CN=C4)=[CH:27][C:19]=12>>[I:17][C:18]1[CH:23]=[N:22][C:21]([NH2:24])=[C:20]2[O:25][C:26]([C:28]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:29]=3)=[CH:27][C:19]=12

Participants

3

Reactant 2

HCID 667594744-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amineHCID 667601712-Phenylfuro[2,3-c]pyridin-7-amine

Product 1

HCID 667599164-Iodo-2-phenylfuro[2,3-c]pyridin-7-amineYield 65%

Procedure

The title compound was prepared in 65% yield from 2-phenylfuro[2,3-c]pyridin-7-amine by a procedure analogous to Intermediate 10, Step B. 1H NMR (300 MHz, CDCl3): δ ppm 4.84 (brs, 2H), 6.87 (s, 1H), 7.40-7.55 (m, 3H), 7.85-7.88 (m, 2H), 8.08 (s, 1H).

Sources & evidence

ORD record
ord-721a37e5f1d6432e84057236f0f763a3
Source dataset
uspto-grants-2013_02
Patent number
US08378104B2

Reaction notes

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