1-Propanamine, N-ethyl- → N-Ethyl-N-{[(2S)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}propan-1-amine

Participants

Role	Name	HCID	Charge
Reactant	1-Propanamine, N-ethyl-	HCID 88398	—
Reactant	[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate	HCID 86652939	—
Solvent	Acetonitrile	HCID 6342	—
Product	N-Ethyl-N-{[(2S)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}propan-1-amine	HCID 67199634	—

Reaction Steps

Preparation according to Example 57 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.027 g, 0.062 mmol), N-ethylpropan-1-amine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 347 (M+, 0.2), 101 (7), 100 (bp), 98 (5), 72 (8), 58 (9).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08524766B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-7f68cfbe9e8e4e7f854fbaf9a291f340
Source note	uspto-grants-2013_09