Hydrochloric Acid → HCID 53379250, compound

Participants

Reaction Steps

A solution of tert-butyl 4-[4-(7-amino-3-chloro-2-phenylfuro[2,3-c]pyridin-4-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate in DCM (1.0 mL) was treated with HCl (1 M in Et2O, 2.0 mL, 2.0 mmol) and stirred at RT. The reaction was concentrated in vacuo to provide 43 mg (76%) of the title compound. 1H NMR (400 MHz, CD3OD) δ 6.94-6.98 (m, 2H), 6.80 (s, 1H), 6.53 (s, 1H), 6.32-6.36 (m, 4H), 3.40 (tt, J=9.98, 4.93 Hz, 1H), 2.34 (dt, J=13.26, 3.35 Hz, 2H), 1.94-2.00 (m, 2H), 1.05-1.15 (m, 4H); MS (ESI): 394.14 [M+H]+; HPLC tR=0.97 min (TOF: polar—3 min).

Provenance & Evidence