Hydrochloric Acid → HCID 66759801, compound

Participants

Reaction Steps

A solution of crude tert-butyl 4-{4-[7-amino-2-(1H-indazol-5-yl)furo[2,3-c]pyridine-4-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate (from Step A) in EtOAc was treated with HCl (4 M in EtOAc, 5 mL, 5 mmol) for 60 min. The reaction was filtered to afford 24 mg (60%) of the title compound. 1H NMR (400 MHz, CD3OD): δ 8.89 (s, 1 H), 8.41 (s, 1 H), 8.08 (s, 1 H), 8.04 (d, J=7.07 Hz, 1 H), 7.89 (s, 1 H), 7.86 (s, 1 H), 7.78 (d, J=8.59 Hz, 1 H), 7.57-7.63 (m, 1 H), 4.67-4.77 (m, 1 H), 3.57-3.65 (m, 2 H), 3.22-3.29 (m, 2 H), 2.37-2.46 (m, 4 H); MS (ESI): 400.09 [M+H]+; HPLC tR=1.81 min.

Provenance & Evidence