Hydrochloric Acid → HCID 53378070, compound

Participants

Reaction Steps

A solution of tert-butyl 3-{4-[7-amino-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}azetidine-1-carboxylate in DCM (10 mL) was treated with HCl (4 M in 1,4-dioxane, 2.57 mL, 10.3 mmol) and stirred at RT for 16 h. The reaction was then concentrated in vacuo to a solid which was purified by MDP to afford 1.3 mg (1%) of the title compound. 1H NMR (400 MHz, CD3OD) δ 9.77 (br. s, 1H), 8.93 (d, J=6.32 Hz, 1H), 8.70 (d, J=7.33 Hz, 2H), 8.59 (d, J=8.34 Hz, 1H), 8.41 (s, 1H), 8.21 (s, 1H), 8.11 (t, J=7.96 Hz, 1H), 7.91 (d, J=4.29 Hz, 2H), 5.58 (s, 1H), 4.63 (dd, 4H); MS (ESI): 383.15 [M+H]+; HPLC tR=0.72 min (TOF: polar—3 min).

Provenance & Evidence