3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-6-carbonitrile → HCID 66760612, compound

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Reaction Steps

The title compound was prepared in 60% yield from 1-{4-[4-(7-amino-2-chloro-furo[2,3-c]pyridin-4-yl)-4,5-dihydro-pyrazol-1-yl]-piperidin-1-yl}ethanone and 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole-6-carbonitrile by a procedure analogous to Example 213. 1H NMR (600 MHz, CD3OD): δ 1.99-2.02 (m, 2H), 2.12 (s, 3H), 2.14-2.24 (m, 2H), 2.84-2.88 (m, 1H), 3.29-3.38 (m, 1H), 4.07-4.11 (m, 1H), 4.52-4.54 (m, 1H), 4.67-4.70 (m, 1H), 7.25 (s, 1H), 7.51 (d, J=7.8 Hz, 1H), 7.84 (s, 1H), 7.89 (s, 1H), 7.92 (s, 1H), 8.15 (s, 1H), 8.25 (s, 1H), 8.39 (d, J=8.0 Hz, 1H); MS (ESI): 466 [M+H]+.

Provenance & Evidence