Isopropanol → 7-Bromo-4-fluoro-1,2-benzothiazole

Temperature

70 °C

A mixture of 3-bromo-2-(tert-butylsulfanyl)-6-fluorobenzaldehyde (1.20 g, 4.12 mmol) and hydroxylamine hydrochloride (1.432 g, 20.60 mmol) in isopropanol (60 mL, 800 mmol) and water (10 mL) was heated to 70° C. for 20 min. The organic solvent was removed in vacuo, and saturated aqueous sodium bicarbonate was added to bring the pH to 8.5. The material was extracted with DCM and water, and the organic layer was concentrated in vacuo. The residue was treated with p-toluenesulfonic acid (141.9 mg, 0.8242 mmol) in n-butanol (60 mL) and the solution was heated to 120° C. overnight. The solvent was removed in vacuo. The residue was purified by column chromatography (1 to 2% EtOAc:hexanes) to afford 382 mg (40%) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3): δ 7.01 (dd, J=9.1, 8.3 Hz, 1 H), 7.60 (dd, J=8.3, 4.0 Hz, 1 H), 9.10 (s, 1 H).

1. customThe organic solvent was removed in vacuo, and saturated aqueous sodium bicarbonate
2. additionwas added
3. extractionThe material was extracted with DCM and water
4. concentrationthe organic layer was concentrated in vacuo
5. temperaturethe solution was heated to 120° C. overnight
6. customThe solvent was removed in vacuo
7. customThe residue was purified by column chromatography (1 to 2% EtOAc:hexanes)

ORD record

ord-62814ca4646d4a0fb1fd6826a046a100

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08378104B2