Pyridinium chloride → HCID 178515387, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-ethoxythieno[2,3-c]pyridine (127 mg, 0.700 mmol), pyridine hydrochloride (827 mg, 7.00 mmol) and H2O (1.2 mL) was heated in a microwave reactor at 175° C. for 2 h. The reaction mixture was concentrated in vacuo and purified by ISCO chromatography (0 to 15% MeOH:DCM) to afford 58.7 mg (55%) of the title compound as a brown solid. 1H NMR (400 MHz, CDCl3): δ 14.04 (br s, 1 H), 8.12 (s, 1 H), 7.66 (d, J=5.6 Hz, 1 H), 7.07 (dd, J=5.6, 0.4 Hz, 1 H), 6.95 (d, J=0.8 Hz, 1 H); MS (ESI): 152.02 [M+H]+; HPLC tR=0.74 min (TOF: polar—3 min).

Provenance & Evidence