Acetic Anhydride → HCID 178473826, compound

Participants

Reaction Steps

To a mixture of 3-{7-amino-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-2-yl}thieno[2,3-c]pyridin-5-ol bis(trifluoroacetate) (40 mg, 0.061 mmol), THF (3 mL), and DMF (1.5 mL) was added triethylamine (72 μl, 0.52 mmol) followed by acetic anhydride (5.9 μl, 0.61 mmol). After stirring at RT for 1 h, the reaction mixture was concentrated in vacuo, and was then purified by MDP to afford 2.0 mg (5%) of the title compound as a yellow paste. 1H NMR (400 MHz, DMSO-d6): δ 13.72 (br s, 1 H), 8.86 (s, 1 H), 8.74 (s, 1 H), 8.56 (br s, 2 H), 8.48 (d, J=0.8 Hz, 1 H), 8.12 (d, J=0.8 Hz, 1 H), 7.96 (s, 1 H), 7.88 (s, 1 H), 7.67 (s, 1 H), 4.48-4.58 (m, 2 H), 3.94-4.01 (m, 1 H), 3.22-3.31 (m, 1 H), 2.73-2.82 (m, 1 H), 2.07-2.18 (m, 2 H), 2.07 (s, 3 H), 1.79-2.02 (m, 2 H); MS (ESI): 475.14 [M+H]+; HPLC tR=0.96 min (TOF: polar—3 min).

Provenance & Evidence