Disiloxane → trans-3-[4-(7-Amino-2-benzo[d]isothiazol-7-yl-furo[2,3-c]pyridin-4-yl)-pyrazol-1-yl]-cyclohexanol

Participants

Reaction Steps

The title compound was prepared from 2-(1,2-benzothiazol-7-yl)-4-iodofuro[2,3-c]pyridin-7-amine and 2-[3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole by a procedure analogous to Example 68 followed by silyl ether deprotection by a procedure analogous to Example 229. 1H NMR (400 MHz, CD3OD): δ 9.48 (s, 1H), 9.09 (s, 1H), 8.84 (d, J=5.9 Hz, 1H), 8.71 (d, J=5.9 Hz, 1H), 8.32 (s, 1H), 8.04 (s, 1H), 7.90 (s, 1H), 7.87 (s, 1H), 4.73 (m, 1H), 3.30 (m, 1H), 2.20 (m, 2H), 2.03 (m, 1H), 1.92 (m, 1H), 1.84 (m, 1H), 1.76 (m, 1H), 1.63 (m, 1H), 1.40 (m, 1H); MS (ESI): 432.60 [M+H]+; HPLC tR=0.60 min (HPLC: Analytical—2 min)

Provenance & Evidence