Benzenepropanoic acid → HCID 66761187, compound

Participants

Reaction Steps

To a solution of 4-(1-piperidin-4-yl-1H-pyrazol-4-yl)-2-thieno[2,3-c]pyridin-3-yl-furo[2,3-c]pyridin-7-ylamine (20.8 mg, 0.05 mmol) in DMF (0.5 mL) was added diisopropylethylamine (0.05 mL, 6.5 mmol), dihydrocinnamic acid (0.06 mmol), and N-(3-dimethylaminopropyl)-N′-ethylcarbodimide hydrochloride (13.5 mg, 0.07 mmol). The resulting solution was allowed to stir at room temperature overnight. The mixture was concentrated and then purified by MDP to afford the title compound. 1H NMR (400 MHz, CD3OD): δ 9.50 (s, 1H), 9.10 (s, 1H), 8.59 (d, J=6.1 Hz, 1H), 8.72 (d, J=6.1 Hz, 1H), 8.28 (s, 1H), 8.05 (s, 1H), 7.88 (s, 1H), 7.87 (s, 1H), 7.28 (s, 5H), 4.54 (m, 1H), 4.04 (m, 2H), 3.10 (m, 2H), 2.99 (m, 2H), 2.67 (m, 2H), 2.19 (m, 2H), 1.95 (m, 2H); MS (ESI): 549.64 [M+H]+; HPLC tR=0.86 min (HPLC: Analytical—2 min).

Provenance & Evidence