HCID 66697928, compound → HCID 66760644, compound

Participants

Reaction Steps

The title compound was prepared in 3% yield from 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phthalazine and 1-{4-[4-(7-amino-2-chlorofuro[2,3-c]pyridin-4-yl)-1H-pyrazol-1-yl]piperidin-1-yl}ethanone, by a procedure analogous to Example 223, Step D. The sample underwent both mass-directed purification and preparative TLC during purification. 1H NMR (400 MHz, CD3OD): δ 10.32 (s, 1H), 9.73 (s, 1H), 8.63 (dd, J=0.76, 7.58 Hz, 1H), 8.32 (d, J=8.08 Hz, 1H), 8.18-8.25 (m, 2H), 7.96-8.03 (m, 2H), 7.76 (s, 1H), 4.67-4.76 (m, 1H), 4.55-4.61 (m, 1H), 3.35-3.42 (m, 1H), 2.88 (dt, J=2.65, 12.95 Hz, 1H), 2.21-2.31 (m, 2H), 2.19 (s, 3H), 1.98-2.18 (m, 3H); MS (ESI): 454.19 [M+H]+; HPLC tR=0.85 min (TOF: polar—3 min).

Provenance & Evidence